The Hardest Ascensions in STS2 (And How to Beat Them)

PC Game

Year2026

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Some Ascensions barely matter… others change the way you should play the game. I ranked every Ascension in Slay the Spire 2 by how hard they actually are—and broke down strategies on how I consistently mitigate them and win my ascension runs. In this video you'll find: Full Ascension difficulty ranking (easiest → hardest) Practical strategies to mitigate each downside Tips to improve consistency and decision-making Whether you’re stuck climbing or just want cleaner runs, this should help you level up. T-Shirt Preorder Link: https://forms.gle/p11HJSApDoZkk9WA9 Timestamps: 00:00 Intro 00:29 1 02:17 2 04:07 3 05:55 4 07:06 5 08:49 6 10:29 7 12:26 8 13:55 9 14:43 10 17:00 Shirt Pre-Order