Pick These Cards EVERY Run | Slay the Spire 2 Guide

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Year2026

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Slay the Spire 2 Guide shows you the best cards to pick every run. These are the most consistent and powerful card rewards in STS2. In this video, I break down the cards that are almost always correct to take when you see them. These aren’t niche picks or “it depends” situations. These are high-impact, consistent cards that make your runs stronger no matter what build you're going for. If you’ve ever struggled with consistency, bad decks, or runs falling apart late… this will fix that. We’ll go character by character and cover: - The best “always pick” cards - Why they’re so strong - When (if ever) you should skip them If you start picking these cards consistently, your win rate will go up. Simple as that. MORE STS2 CONTENT ▶ Beginner Guides: - Ironclad Guide: https://youtu.be/XoY_9fW4wnE - Silent Guide: https://youtu.be/BzG-EXLhlyE - Defect Guide: https://youtu.be/LRF5rmu9utY - Necrobinder Guide: https://youtu.be/5O80ew1vdwg - Regent Guide: https://youtu.be/Nz3bDcXIAKs ▶ Other Guides: - Stop Skipping Elites: https://youtu.be/VxvOCMBde4k - Pathing Guide: https://youtu.be/kdSsSzSALE8 - Deck Building Guide: https://youtu.be/57cMJltTNyE - Mistakes Wrecking Your Runs: https://youtu.be/6SDxBWzjFGI And check out my twitch link below. I stream Monday, Tuesday, Thursday, and Friday night at 9pm EST on twitch. https://www.twitch.tv/nerdyhickey https://www.twitter.com/rhickey28 https://www.tiktok.com/@nerdyhickey #slaythespire2 #slaythespire #roguelike #deckbuilder